The Centre for Genomic Regulation (CRG) is an innovative centre for basic research created in December 2000 by initiative of the former Department of Universities, Research and Information Society (DURSI) of the Catalan Government. The CRG is legally constituted as a non-profit foundation and has the participation of the Catalan Government through the Innovation, Universities and Enterprise Department (DIUE) and the Health Department (DS), as well as of the Pompeu Fabra University (UPF), and the Spanish Ministry of Science and Innovation (MICINN). Two groups are involved in the CLL Project:
- The Genetic Causes of Disease Group, lead by Xavier Estivill, focuses its research on the analysis of the variability of the human genome at the nucleotide and genomic levels and their relation with disease predisposition. It is also interested in studying the contribution of non-coding RNAs and structural variation to human disease. The contribution of this group to the project focuses on the analysis of structural variations and genomic abnormalities that are either involved in disease predisposition or that participate in the CLL evolution. The group also analyses the role of non-coding RNAs (including micro RNAs) in CLL; and integrates the use of several algorithms to explore whole genome sequencing and long-insert mate paired libraries, and non-coding RNA libraries in next generation sequencing data sets. The group is also analysing the contribution of transposable elements and of microbial sequences in the development and evolution of the CLL phenotype.
- The Bioinformatics and Genomics Group, lead by Roderic Guigó, focuses on the investigation of the signals involved in gene specification in genomic sequences (promoter elements, splice sites, translation initiation sites...). The group is interested both in the mechanism of their recognition and processing, and in their evolution. In addition, but related to this basic component of our research, our group is also involved in the development of software for gene prediction and annotation in genomic sequences. The role of the group in the chronic lymphocytic leukaemia (CLL) project is the analysis of transcriptomes based on RNASeq experiments. We are developing methods to use RNASeq data for transcript discovery and quantification. The overall goal is to identify and understand the transcriptome changes associated to CLL, with the aim both of understanding the causes of CLL phenotype and of finding appropriate molecular markers. One particular interest of our group is the investigation of the expression changes in long non-coding RNAs.
Genetic Causes of Disease Group
Bioinformatics and Genomics Group